Actin is a major component of the cytoskeleton in eukaryotic cells and plays a crucial role in various cellular processes, including cell motility, cell division, and cell shape determination. Actin interacts with a plethora of proteins to regulate its polymerization, depolymerization, and organization within the cell. Research on actin interactions focuses on elucidating the molecular mechanisms underlying the regulation of actin dynamics and its interactions with other proteins. This includes studying how actin-binding proteins control actin filament assembly and disassembly, how actin filaments are organized into higher-order structures, and how actin interacts with motor proteins to generate force for cell movement. Additionally, research on actin interactions also investigates how dysregulation of actin dynamics and interactions contribute to various diseases, such as cancer, neurodegenerative disorders, and autoimmune diseases. Understanding actin interactions at the molecular level is essential for developing targeted therapies for these diseases.